Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore considered positive facilitators of transcription....

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Detalles Bibliográficos
Autores principales: Herrero-Ruiz, Andrés, Martínez-García, Pedro Manuel, Terrón-Bautista, José, Millán-Zambrano, Gonzalo, Lieberman, Jenna Ariel, Jimeno-González, Silvia, Cortés-Ledesma, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052185/
https://www.ncbi.nlm.nih.gov/pubmed/33852840
http://dx.doi.org/10.1016/j.celrep.2021.108977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052185/
https://www.ncbi.nlm.nih.gov/pubmed/33852840
http://dx.doi.org/10.1016/j.celrep.2021.108977

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