A cell based assay for evaluating binding and uptake of an antibody using hepatic nonparenchymal cells

Evaluation of the binding and uptake of an antibody in liver non-parenchymal cells (NPC), including liver sinusoidal endothelial cells, is important for revealing its pharmacokinetic (PK) behavior, since NPC has important roles in eliminating an antibody from the blood via the Fc fragment of IgG rec...

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Detalles Bibliográficos
Autores principales: Noguchi, Yuki, Ozeki, Kazuhisa, Takesue, Hiroaki, Akita, Hidetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052349/
https://www.ncbi.nlm.nih.gov/pubmed/33863984
http://dx.doi.org/10.1038/s41598-021-87912-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052349/
https://www.ncbi.nlm.nih.gov/pubmed/33863984
http://dx.doi.org/10.1038/s41598-021-87912-6

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