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A cell based assay for evaluating binding and uptake of an antibody using hepatic nonparenchymal cells
Evaluation of the binding and uptake of an antibody in liver non-parenchymal cells (NPC), including liver sinusoidal endothelial cells, is important for revealing its pharmacokinetic (PK) behavior, since NPC has important roles in eliminating an antibody from the blood via the Fc fragment of IgG rec...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052349/ https://www.ncbi.nlm.nih.gov/pubmed/33863984 http://dx.doi.org/10.1038/s41598-021-87912-6 |