Functional disability is related to serum chemerin levels in rheumatoid arthritis

Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability and chemerin and other pro-inflammatory molecules in rheumatoid arthritis (RA). To identify the...

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Detalles Bibliográficos
Autores principales: Vazquez-Villegas, Maria Luisa, Gamez-Nava, Jorge I., Saldaña-Cruz, A. Miriam, Celis, Alfredo, Sanchez-Rodriguez, Esther N., Perez-Guerrero, Edsaul Emilio, Ramirez-Villafaña, Melissa, Nava-Valdivia, Cesar Arturo, Contreras-Haro, Betsabe, Vasquez-Jimenez, Jose C., Ponce-Guarneros, Juan M., Barocio-Ramirez, Ana K., Cerpa-Cruz, Sergio, Alcaraz-Lopez, Miriam F., Gonzalez-Lopez, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052358/
https://www.ncbi.nlm.nih.gov/pubmed/33863926
http://dx.doi.org/10.1038/s41598-021-87235-6
Descripción
Sumario:Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability and chemerin and other pro-inflammatory molecules in rheumatoid arthritis (RA). To identify the association of functional disability with serum chemerin and other pro-inflammatory molecules, including other adipokines, cytokines and E-selectin, in patients with RA. Cross-sectional study. Assessment: disease activity (DAS28-ESR) and functional disability (HAQ-DI). We compared the adipokines (chemerin, leptin, adiponectin, resistin, and visfatin), cytokines (TNF-α, IL-6, IL-1β, and IL-18) and E-selectin levels between RA with functional disability and RA non-disabled patients. Of 82 patients with RA, 43 (52%) had functional disability. The RA with functional disability group had higher chemerin (140 vs. 112 ng/mL, p = 0.007) than the non-disabled RA group. Chemerin correlated with the HAQ-DI (rho = 0.27, p = 0.02) and DAS28-ESR (rho = 0.21, p = 0.05). Severe activity correlated with IL-6 (rho = 0.33, p = 0.003) and E-selectin (rho = 0.23, p = 0.03) but not with disability. No other pro-inflammatory molecules correlated with HAQ-DI. High chemerin levels were associated with functional disability in RA, whereas no other molecules correlated with loss of function. These results encourage further studies assessing new roles of chemerin as a marker of impairment in RA.