Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells

Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that do not express MHC I or MHC II. Instead, cortical thymocytes express non-peptide presenting MHC molecules like CD1d and MR1, and promote the selection...

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Detalles Bibliográficos
Autores principales: Georgiev, Hristo, Peng, Changwei, Huggins, Matthew A., Jameson, Stephen C., Hogquist, Kristin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052364/
https://www.ncbi.nlm.nih.gov/pubmed/33863906
http://dx.doi.org/10.1038/s41467-021-22589-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052364/
https://www.ncbi.nlm.nih.gov/pubmed/33863906
http://dx.doi.org/10.1038/s41467-021-22589-z

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