Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses

Major depressive disorder (MDD) is associated with alterations of GABAergic interneurons, notably somatostatin (Sst) as well as parvalbumin (Pvalb), in cortical brain areas. In addition, the antidepressant effects of rapid acting drugs are thought to occur via inhibition of GABA interneurons. Howeve...

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Detalles Bibliográficos
Autores principales: Fogaça, Manoela V., Wu, Min, Li, Chan, Li, Xiao-Yuan, Picciotto, Marina R., Duman, Ronald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052382/
https://www.ncbi.nlm.nih.gov/pubmed/33070149
http://dx.doi.org/10.1038/s41380-020-00916-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052382/
https://www.ncbi.nlm.nih.gov/pubmed/33070149
http://dx.doi.org/10.1038/s41380-020-00916-y

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