Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity

Approximately 15–30% of patients with lung cancer harbor mutations in the EGFR gene. Major EGFR mutations (>90% of EGFR-mutated lung cancer) are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs). Many uncommon EGFR mutations have been identified, but little is known regarding their chara...

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Detalles Bibliográficos
Autores principales: Yoshizawa, Takahiro, Uchibori, Ken, Araki, Mitsugu, Matsumoto, Shigeyuki, Ma, Biao, Kanada, Ryo, Seto, Yosuke, Oh-hara, Tomoko, Koike, Sumie, Ariyasu, Ryo, Kitazono, Satoru, Ninomiya, Hironori, Takeuchi, Kengo, Yanagitani, Noriko, Takagi, Satoshi, Kishi, Kazuma, Fujita, Naoya, Okuno, Yasushi, Nishio, Makoto, Katayama, Ryohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052404/
https://www.ncbi.nlm.nih.gov/pubmed/33863983
http://dx.doi.org/10.1038/s41698-021-00170-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052404/
https://www.ncbi.nlm.nih.gov/pubmed/33863983
http://dx.doi.org/10.1038/s41698-021-00170-7

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