Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease

The Streptococcal C5a peptidase (ScpA) specifically inactivates the human complement factor hC5a, a potent anaphylatoxin recently identified as a therapeutic target for treatment of COVID-19 infections. Biologics used to modulate hC5a are predominantly monoclonal antibodies. Here we present data to...

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Detalles Bibliográficos
Autores principales: Teçza, Malgorzata, Kagawa, Todd F., Jain, Monica, Cooney, Jakki C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052502/
https://www.ncbi.nlm.nih.gov/pubmed/33897974
http://dx.doi.org/10.1016/j.csbj.2021.04.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052502/
https://www.ncbi.nlm.nih.gov/pubmed/33897974
http://dx.doi.org/10.1016/j.csbj.2021.04.024

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