Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

BACKGROUND: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome (PCOS). METHODS: PCOS mouse model was establi...

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Detalles Bibliográficos
Autores principales: Zhu, Bo, Chen, Yumei, Xu, Fang, Shen, Xiaolu, Chen, Xuanyu, Lv, Jieqiang, Zhang, Songying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052571/
https://www.ncbi.nlm.nih.gov/pubmed/33543730
http://dx.doi.org/10.1530/EC-20-0608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052571/
https://www.ncbi.nlm.nih.gov/pubmed/33543730
http://dx.doi.org/10.1530/EC-20-0608

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