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Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress

BACKGROUND: Androgens excess results in endoplasmic reticulum (ER) stress, which is an important cause of β cells dysfunction. Here, we investigated the molecular regulation of androgens excess, ER stress, and β-cell function in polycystic ovary syndrome (PCOS). METHODS: PCOS mouse model was establi...

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Detalles Bibliográficos
Autores principales:	Zhu, Bo, Chen, Yumei, Xu, Fang, Shen, Xiaolu, Chen, Xuanyu, Lv, Jieqiang, Zhang, Songying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052571/ https://www.ncbi.nlm.nih.gov/pubmed/33543730 http://dx.doi.org/10.1530/EC-20-0608

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