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MEK inhibitors - novel targeted therapies of neurofibromatosis associated benign and malignant lesions
MAP/ERK kinase 1 and 2 (MEK 1/2) inhibitors (MEKi) are investigated in several trials to treat lesions that arise from pathogenic variants of the Neurofibromatosis type 1 and type 2 genes (NF1, NF2). These trials showed that MEKi are capable to shrink volume of low grade gliomas and plexiform neurof...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052700/ https://www.ncbi.nlm.nih.gov/pubmed/33863389 http://dx.doi.org/10.1186/s40364-021-00281-0 |