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TriBAFF-CAR-T cells eliminate B-cell malignancies with BAFFR-expression and CD19 antigen loss

BACKGROUND: To investigate the effect of TriBAFF-CAR-T cells on hematological tumor cells. METHODS: TriBAFF-CAR-T and CD19-CAR-T cells were co-cultured with BAFFR-bearing B-cell malignancies at different effector/target ratios to evaluate the anti-tumor effects. In vivo, TriBAFF-CAR-T and CD19-CAR-T...

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Detalles Bibliográficos
Autores principales:	Li, Guangchao, Zhang, Qing, Liu, Zhi, Shen, Huijuan, Zhu, Yangmin, Zhou, Zhao, Ding, Wen, Han, Siqi, Zhou, Jie, Ou, Ruiming, Luo, Min, Liu, Shuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052726/ https://www.ncbi.nlm.nih.gov/pubmed/33865370 http://dx.doi.org/10.1186/s12935-021-01923-x

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