mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus

BACKGROUND: Tuberous sclerosis complex (TSC), a multi-system genetic disorder often associated with autism spectrum disorder (ASD), is caused by mutations of TSC1 or TSC2, which lead to constitutive overactivation of mammalian target of rapamycin (mTOR). In several Tsc1+/- and Tsc2+/- animal models,...

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Detalles Bibliográficos
Autores principales: Petrasek, Tomas, Vojtechova, Iveta, Klovrza, Ondrej, Tuckova, Klara, Vejmola, Cestmir, Rak, Jakub, Sulakova, Anna, Kaping, Daniel, Bernhardt, Nadine, de Vries, Petrus J., Otahal, Jakub, Waltereit, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052752/
https://www.ncbi.nlm.nih.gov/pubmed/33863288
http://dx.doi.org/10.1186/s11689-021-09357-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052752/
https://www.ncbi.nlm.nih.gov/pubmed/33863288
http://dx.doi.org/10.1186/s11689-021-09357-2

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