Cargando…

mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus

BACKGROUND: Tuberous sclerosis complex (TSC), a multi-system genetic disorder often associated with autism spectrum disorder (ASD), is caused by mutations of TSC1 or TSC2, which lead to constitutive overactivation of mammalian target of rapamycin (mTOR). In several Tsc1+/- and Tsc2+/- animal models,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petrasek, Tomas, Vojtechova, Iveta, Klovrza, Ondrej, Tuckova, Klara, Vejmola, Cestmir, Rak, Jakub, Sulakova, Anna, Kaping, Daniel, Bernhardt, Nadine, de Vries, Petrus J., Otahal, Jakub, Waltereit, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052752/ https://www.ncbi.nlm.nih.gov/pubmed/33863288 http://dx.doi.org/10.1186/s11689-021-09357-2

Ejemplares similares

Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters
por: Vojtechova, Iveta, et al.
Publicado: (2021)

The impact of constitutive mTORC1 hyperactivity on structural synaptic plasticity and social behaviour under standard conditions and environmental enrichment
por: Granak, S., et al.
Publicado: (2022)

Treatment With Resveratrol Ameliorates Mitochondrial Dysfunction During the Acute Phase of Status Epilepticus in Immature Rats
por: Folbergrová, Jaroslava, et al.
Publicado: (2021)

Protective Effect of Sulforaphane on Oxidative Stress and Mitochondrial Dysfunction Associated with Status Epilepticus in Immature Rats
por: Folbergrová, Jaroslava, et al.
Publicado: (2023)

Status Epilepticus in Immature Rats Is Associated with Oxidative Stress and Mitochondrial Dysfunction
por: Folbergrová, Jaroslava, et al.
Publicado: (2016)

Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum
por: Serra, Ines, et al.
Publicado: (2022)

Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunity
por: Vojtechova, Iveta, et al.
Publicado: (2022)

Memantine and Riluzole Exacerbate, Rather Than Ameliorate Behavioral Deficits Induced by 8-OH-DPAT Sensitization in a Spatial Task
por: Janikova, Martina, et al.
Publicado: (2021)

Sulforaphane Ameliorates Metabolic Changes Associated With Status Epilepticus in Immature Rats
por: Daněk, Jan, et al.
Publicado: (2022)

Tsc2 Haploinsufficiency Has Limited Effects on Fetal Brain Cytokine Levels during Gestational Immune Activation
por: Ehninger, Dan
Publicado: (2014)

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation
por: Peri, Suraj, et al.
Publicado: (2016)

Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
por: Tsai, Peter T., et al.
Publicado: (2012)

Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice
por: Macháček, Tomáš, et al.
Publicado: (2022)

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
por: Hoogeveen-Westerveld, Marianne, et al.
Publicado: (2012)

Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice
por: Moore, Spencer M., et al.
Publicado: (2019)

A Rat Model of Alzheimer’s Disease Based on Abeta(42) and Pro-oxidative Substances Exhibits Cognitive Deficit and Alterations in Glutamatergic and Cholinergic Neurotransmitter Systems
por: Petrasek, Tomas, et al.
Publicado: (2016)

Psilocin, LSD, mescaline, and DOB all induce broadband desynchronization of EEG and disconnection in rats with robust translational validity
por: Vejmola, Čestmír, et al.
Publicado: (2021)

Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats
por: Šíchová, Klára, et al.
Publicado: (2018)

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D(2) 3,4-dihydroquinolin-2(1H)-one Derivatives Related to Aripiprazole
por: Juza, Radomir, et al.
Publicado: (2021)

Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior
por: Smith, Gregory D., et al.
Publicado: (2016)

Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
por: Tyburczy, Magdalena E., et al.
Publicado: (2015)

Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2
por: Kwiatkowski, David J, et al.
Publicado: (2015)

Evidence for population variation in TSC1 and TSC2 gene expression
por: Jentarra, Garilyn M, et al.
Publicado: (2011)

The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity
por: Petrasek, Tomas, et al.
Publicado: (2018)

Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats—pharmacokinetics, effects on behaviour and thermoregulation
por: Syrová, Kateřina, et al.
Publicado: (2023)

Analysis of the TSC1and TSC2genes in sporadic renal cell carcinomas
por: Parry, L, et al.
Publicado: (2001)

Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
por: Liu, Jie, et al.
Publicado: (2019)

Germline mutation of TSC1 or TSC2 gene in Chinese patients with bilateral renal angiomyolipomas and mutation spectrum of Chinese TSC patients
por: Jiangyi, Wang, et al.
Publicado: (2020)

Na(V)1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age
por: Léna, Isabelle, et al.
Publicado: (2019)

Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex
por: Li, Yi, et al.
Publicado: (2018)

Mutational analysis of TSC1 and TSC2 in Danish patients with tuberous sclerosis complex
por: Rosengren, Thomas, et al.
Publicado: (2020)

Correction: Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
por: Liu, Jie, et al.
Publicado: (2020)

Electrical Source Imaging in Freely Moving Rats: Evaluation of a 12-Electrode Cortical Electroencephalography System
por: Jiricek, Stanislav, et al.
Publicado: (2021)

Functional characterisation of the TSC1–TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex
por: Nellist, Mark, et al.
Publicado: (2008)

Convulsive status epilepticus as a possible symptom of COVID-19 in a patient with intellectual disability and autistic spectrum disorder
por: Peña-Salazar, C., et al.
Publicado: (2020)

Drosophila yakuba – Tsc1
por: Lose, Bailey, et al.
Publicado: (2021)

Drosophila yakuba – Tsc1
por: Lose, Bailey, et al.
Publicado: (2021)

Targeted Next Generation Sequencing reveals previously unidentified TSC1 and TSC2 mutations
por: Nellist, Mark, et al.
Publicado: (2015)

Primary TSC2(-/meth) Cells Induce Follicular Neogenesis in an Innovative TSC Mouse Model
por: Bernardelli, Clara, et al.
Publicado: (2022)

Kv1.1 deficiency alters repetitive and social behaviors in mice and rescues autistic‐like behaviors due to Scn2a haploinsufficiency
por: Indumathy, Jagadeeswaran, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s8st2u1iui2evono271mqjq2r9