Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles

A single amino acid residue change in the exonuclease domain of human DNA polymerase ϵ, P286R, is associated with the development of colorectal cancers, and has been shown to impart a mutator phenotype. The corresponding Pol ϵ allele in the yeast Saccharomyces cerevisiae (pol2-P301R), was found to d...

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Detalles Bibliográficos
Autores principales: Herzog, Mareike, Alonso-Perez, Elisa, Salguero, Israel, Warringer, Jonas, Adams, David J, Jackson, Stephen P, Puddu, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053093/
https://www.ncbi.nlm.nih.gov/pubmed/33764464
http://dx.doi.org/10.1093/nar/gkab160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053093/
https://www.ncbi.nlm.nih.gov/pubmed/33764464
http://dx.doi.org/10.1093/nar/gkab160

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