Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity. Here, we report crystal structures of Thermus oshim...

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Detalles Bibliográficos
Autores principales: Dai, Yang-Xue, Chen, Wei-Fei, Liu, Na-Nv, Teng, Fang-Yuan, Guo, Hai-Lei, Hou, Xi-Miao, Dou, Shuo-Xing, Rety, Stephane, Xi, Xu-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053095/
https://www.ncbi.nlm.nih.gov/pubmed/33784404
http://dx.doi.org/10.1093/nar/gkab188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053095/
https://www.ncbi.nlm.nih.gov/pubmed/33784404
http://dx.doi.org/10.1093/nar/gkab188

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