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Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition
Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity. Here, we report crystal structures of Thermus oshim...
Autores principales: | Dai, Yang-Xue, Chen, Wei-Fei, Liu, Na-Nv, Teng, Fang-Yuan, Guo, Hai-Lei, Hou, Xi-Miao, Dou, Shuo-Xing, Rety, Stephane, Xi, Xu-Guang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053095/ https://www.ncbi.nlm.nih.gov/pubmed/33784404 http://dx.doi.org/10.1093/nar/gkab188 |
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