Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition

Hydroxamate-based lysine deacetylase inhibitors (KDACis) are approved for clinical use against certain cancers. However, intrinsic and acquired resistance presents a major problem. Treatment of cells with hydroxamates such as trichostatin A (TSA) leads to rapid preferential acetylation of histone H3...

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Detalles Bibliográficos
Autores principales: Huang, Li-Yao, Hsu, Duen-Wei, Pears, Catherine J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053100/
https://www.ncbi.nlm.nih.gov/pubmed/33721015
http://dx.doi.org/10.1093/nar/gkab154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053100/
https://www.ncbi.nlm.nih.gov/pubmed/33721015
http://dx.doi.org/10.1093/nar/gkab154

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