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Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition
Hydroxamate-based lysine deacetylase inhibitors (KDACis) are approved for clinical use against certain cancers. However, intrinsic and acquired resistance presents a major problem. Treatment of cells with hydroxamates such as trichostatin A (TSA) leads to rapid preferential acetylation of histone H3...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053100/ https://www.ncbi.nlm.nih.gov/pubmed/33721015 http://dx.doi.org/10.1093/nar/gkab154 |