RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork

Uracil occurs at replication forks via misincorporation of deoxyuridine monophosphate (dUMP) or via deamination of existing cytosines, which occurs 2–3 orders of magnitude faster in ssDNA than in dsDNA and is 100% miscoding. Tethering of UNG2 to proliferating cell nuclear antigen (PCNA) allows rapid...

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Detalles Bibliográficos
Autores principales: Kavli, Bodil, Iveland, Tobias S, Buchinger, Edith, Hagen, Lars, Liabakk, Nina B, Aas, Per A, Obermann, Tobias S, Aachmann, Finn L, Slupphaug, Geir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053108/
https://www.ncbi.nlm.nih.gov/pubmed/33784377
http://dx.doi.org/10.1093/nar/gkab195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053108/
https://www.ncbi.nlm.nih.gov/pubmed/33784377
http://dx.doi.org/10.1093/nar/gkab195

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