Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension

Nonenzymatic copying of RNA templates with activated nucleotides is a useful model for studying the emergence of heredity at the origin of life. Previous experiments with defined-sequence templates have pointed to the poor fidelity of primer extension as a major problem. Here we examine the origin o...

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Detalles Bibliográficos
Autores principales: Duzdevich, Daniel, Carr, Christopher E, Ding, Dian, Zhang, Stephanie J, Walton, Travis S, Szostak, Jack W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053118/
https://www.ncbi.nlm.nih.gov/pubmed/33744957
http://dx.doi.org/10.1093/nar/gkab173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053118/
https://www.ncbi.nlm.nih.gov/pubmed/33744957
http://dx.doi.org/10.1093/nar/gkab173

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