Cargando…

Effect of small molecule eRF3 degraders on premature termination codon readthrough

Premature termination codon (PTC) readthrough is considered a potential treatment for genetic diseases caused by nonsense mutations. High concentrations of aminoglycosides induce low levels of PTC readthrough but also elicit severe toxicity. Identifying compounds that enhance PTC readthrough by amin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baradaran-Heravi, Alireza, Balgi, Aruna D, Hosseini-Farahabadi, Sara, Choi, Kunho, Has, Cristina, Roberge, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053119/ https://www.ncbi.nlm.nih.gov/pubmed/33764477 http://dx.doi.org/10.1093/nar/gkab194

Ejemplares similares

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2016)

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough
por: Hosseini-Farahabadi, Sara, et al.
Publicado: (2021)

Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2022)

The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418
por: Ferguson, Michael W., et al.
Publicado: (2019)

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
por: Frew, Jonathan, et al.
Publicado: (2020)

Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP
por: Lyu, Zhihui, et al.
Publicado: (2023)

Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough
por: Lee, Rhianna E., et al.
Publicado: (2022)

The unfolded protein response affects readthrough of premature termination codons
por: Oren, Yifat S, et al.
Publicado: (2014)

Ataluren—Promising Therapeutic Premature Termination Codon Readthrough Frontrunner
por: Michorowska, Sylwia
Publicado: (2021)

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR
por: Smith, Emery, et al.
Publicado: (2020)

Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development
por: Li, Shan, et al.
Publicado: (2023)

eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons
por: Yang, Qian, et al.
Publicado: (2019)

Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons
por: Pranke, Iwona, et al.
Publicado: (2018)

Letter to the Editor: Liver Cell Models for Premature Termination Codon Readthrough Analyses
por: Matakovic, Lavinija, et al.
Publicado: (2021)

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons
por: Dabrowski, Maciej, et al.
Publicado: (2018)

Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner
por: Chen, Yanan, et al.
Publicado: (2020)

635 Genome-wide screen to uncover genes promoting premature termination codon readthrough
por: Wong, E., et al.
Publicado: (2022)

Modification of orthogonal tRNAs: unexpected consequences for sense codon reassignment
por: Biddle, Wil, et al.
Publicado: (2016)

Aminoglycoside-stimulated readthrough of premature termination codons in selected genes involved in primary ciliary dyskinesia
por: Bukowy-Bieryllo, Zuzanna, et al.
Publicado: (2016)

MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution
por: Torices, Leire, et al.
Publicado: (2021)

Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria
por: Ling, Jiqiang, et al.
Publicado: (2014)

Expression of the eRF1 translation termination factor is controlled by an autoregulatory circuit involving readthrough and nonsense-mediated decay in plants
por: Nyikó, Tünde, et al.
Publicado: (2017)

Misdecoding of rare CGA codon by translation termination factors, eRF1/eRF3, suggests novel class of ribosome rescue pathway in S. cerevisiae
por: Wada, Miki, et al.
Publicado: (2018)

N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination
por: Urakov, Valery N, et al.
Publicado: (2006)

Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides
por: Wangen, Jamie R, et al.
Publicado: (2020)

New insights into stop codon recognition by eRF1
por: Blanchet, Sandra, et al.
Publicado: (2015)

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
por: Sharma, Jyoti, et al.
Publicado: (2021)

Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3
por: Beißel, Christian, et al.
Publicado: (2019)

Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast
por: Chan, Clara S., et al.
Publicado: (2013)

Readthrough of Premature Termination Codons in the Adenomatous Polyposis Coli Gene Restores Its Biological Activity in Human Cancer Cells
por: Floquet, Célia, et al.
Publicado: (2011)

The Effect of Gentamicin-Induced Readthrough on a Novel Premature Termination Codon of CD18 Leukocyte Adhesion Deficiency Patients
por: Simon, Amos J., et al.
Publicado: (2010)

HELZ2: a new, interferon-regulated, human 3′-5′ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon
por: Huntzinger, Eric, et al.
Publicado: (2023)

Multiple functions for the N-terminal region of Msh6
por: Clark, Alan B., et al.
Publicado: (2007)

Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing eRF1-eRF3 or eRF1-ABCE1
por: Preis, Anne, et al.
Publicado: (2014)

Regulation of T7 gp2.5 binding dynamics by its C-terminal tail, template conformation and sequence
por: Xu, Longfu, et al.
Publicado: (2023)

Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1
por: Wong, Leo E., et al.
Publicado: (2012)

Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides
por: Ashley, Jon, et al.
Publicado: (2021)

Function of the N-terminal segment of the RecA-dependent nuclease Ref
por: Gruber, Angela J., et al.
Publicado: (2015)

The domain structure of Helicobacter pylori DnaB helicase: the N-terminal domain can be dispensable for helicase activity whereas the extreme C-terminal region is essential for its function
por: Nitharwal, Ram Gopal, et al.
Publicado: (2007)

3′-Terminal 2′-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2
por: Liang, Hongwei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cc1r595728l5or0pdk46auoat4