Effect of small molecule eRF3 degraders on premature termination codon readthrough

Premature termination codon (PTC) readthrough is considered a potential treatment for genetic diseases caused by nonsense mutations. High concentrations of aminoglycosides induce low levels of PTC readthrough but also elicit severe toxicity. Identifying compounds that enhance PTC readthrough by amin...

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Detalles Bibliográficos
Autores principales: Baradaran-Heravi, Alireza, Balgi, Aruna D, Hosseini-Farahabadi, Sara, Choi, Kunho, Has, Cristina, Roberge, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053119/
https://www.ncbi.nlm.nih.gov/pubmed/33764477
http://dx.doi.org/10.1093/nar/gkab194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053119/
https://www.ncbi.nlm.nih.gov/pubmed/33764477
http://dx.doi.org/10.1093/nar/gkab194

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