Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough

Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC readthrough and restore low levels of full-length functional proteins. However, concomitant inhibition of protein synthesis limits the extent of P...

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Detalles Bibliográficos
Autores principales: Hosseini-Farahabadi, Sara, Baradaran-Heravi, Alireza, Zimmerman, Carla, Choi, Kunho, Flibotte, Stephane, Roberge, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118496/
https://www.ncbi.nlm.nih.gov/pubmed/33939688
http://dx.doi.org/10.1371/journal.pbio.3001221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118496/
https://www.ncbi.nlm.nih.gov/pubmed/33939688
http://dx.doi.org/10.1371/journal.pbio.3001221

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