Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma

PURPOSE: Isocitrate dehydrogenase 1 (IDH1) mutations are the most common genetic abnormalities in low-grade gliomas and secondary glioblastomas. Glioma patients with these mutations had better clinical outcomes. However, the effect of IDH1 mutation on drug sensitivity is still under debate. MATERIAL...

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Detalles Bibliográficos
Autores principales: Lin, Lin, Cai, Jinquan, Tan, Zixiao, Meng, Xiangqi, Li, Ruiyan, Li, Yang, Jiang, Chuanlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053882/
https://www.ncbi.nlm.nih.gov/pubmed/33070553
http://dx.doi.org/10.4143/crt.2020.506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053882/
https://www.ncbi.nlm.nih.gov/pubmed/33070553
http://dx.doi.org/10.4143/crt.2020.506

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