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Learning the molecular grammar of protein condensates from sequence determinants and embeddings

Intracellular phase separation of proteins into biomolecular condensates is increasingly recognized as a process with a key role in cellular compartmentalization and regulation. Different hypotheses about the parameters that determine the tendency of proteins to form condensates have been proposed,...

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Detalles Bibliográficos
Autores principales: Saar, Kadi L., Morgunov, Alexey S., Qi, Runzhang, Arter, William E., Krainer, Georg, Lee, Alpha A., Knowles, Tuomas P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053968/
https://www.ncbi.nlm.nih.gov/pubmed/33827920
http://dx.doi.org/10.1073/pnas.2019053118