Cargando…

miR-181a, delivered by hypoxic PTC-secreted exosomes, inhibits DACT2 by downregulating MLL3, leading to YAP-VEGF-mediated angiogenesis

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, and angiogenesis plays critical roles in its recurrence and metastasis. In this study, we investigated the effects of hypoxia-induced exosomal microRNA-181 (miR-181a) from PTC on tumor growth and angiogenesis. Thyroid-cancer-r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yingxue, Cen, Aiying, Yang, Yuxian, Ye, Huilin, Li, Jiaying, Liu, Shiliang, Zhao, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054101/ https://www.ncbi.nlm.nih.gov/pubmed/33898109 http://dx.doi.org/10.1016/j.omtn.2021.02.027

Ejemplares similares

Tetramethylpyrazine Ameliorates Peritoneal Angiogenesis by Regulating VEGF/Hippo/YAP Signaling
por: Zhu, Xiaolin, et al.
Publicado: (2021)

Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway
por: Tan, Ying, et al.
Publicado: (2017)

Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma
por: Guo, Yan-li, et al.
Publicado: (2017)

A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis
por: Bora-Singhal, Namrata, et al.
Publicado: (2022)

The Role of DACT Family Members in Tumorigenesis and Tumor Progression
por: Zeng, Yu, et al.
Publicado: (2022)

MicroRNA-181a promotes angiogenesis in colorectal cancer by targeting SRCIN1 to promote the SRC/VEGF signaling pathway
por: Sun, Wu, et al.
Publicado: (2018)

MAD-X PTC Integration
por: Schmidt, Frank, et al.
Publicado: (2005)

Hippo-YAP/TAZ signaling in angiogenesis
por: Park, Jeong Ae, et al.
Publicado: (2018)

Chitosan/Polycyclodextrin (CHT/PCD)-Based Sponges Delivering VEGF to Enhance Angiogenesis for Bone Regeneration
por: Palomino-Durand, Carla, et al.
Publicado: (2020)

CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells
por: Pratheeshkumar, Poyil, et al.
Publicado: (2021)

The role of aberrant promoter hypermethylation of DACT1 in bladder urothelial carcinoma
por: Cheng, Huan, et al.
Publicado: (2012)

DACT2 regulates structural and electrical atrial remodeling in atrial fibrillation
por: Hou, Jian, et al.
Publicado: (2020)

Effects of DACT1 methylation status on invasion and metastasis of nasopharyngeal carcinoma
por: Yang, Ju-Hong, et al.
Publicado: (2019)

First complete mitochondrial genome of Phoenix dact ylifera var. Khanezi
por: Asaf, Sajjad, et al.
Publicado: (2018)

PAFc, a Key Player in MLL-rearranged Leukemogenesis
por: Tan, Jiaying, et al.
Publicado: (2010)

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions
por: Dong, Xiao, et al.
Publicado: (2011)

Advances in MAD-X using PTC
por: Skowronski, P K, et al.
Publicado: (2007)

PTC_py-ORBIT - Release & Benchmarking
por: HOLMES, Jeffrey A
Publicado: (2014)

The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry
por: Azad, Taha, et al.
Publicado: (2019)

Oncogenic Function of DACT1 in Colon Cancer through the Regulation of β-catenin
por: Yuan, Guohong, et al.
Publicado: (2012)

Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling
por: Zhang, Meiying, et al.
Publicado: (2016)

Methylation of DACT2 promotes breast cancer development by activating Wnt signaling
por: Li, Jingyi, et al.
Publicado: (2017)

Downregulation of DACT-2 by Promoter Methylation and its Clinicopathological Significance in Prostate Cancer
por: Li, Shibao, et al.
Publicado: (2019)

Hydrodynamic Modeling and Parameter Identification of a Bionic Underwater Vehicle: RobDact
por: Cao, Qiyuan, et al.
Publicado: (2022)

(188)Rhenium Treatment Induces DACT2 Expression in Hepatocellular Carcinoma Cells
por: Asadian, Samieh, et al.
Publicado: (2022)

MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling
por: Du, Yan-e, et al.
Publicado: (2017)

miR-376a inhibits glioma proliferation and angiogenesis by regulating YAP1/VEGF signalling via targeting of SIRT1
por: Deng, Yong-Wen, et al.
Publicado: (2021)

Dact genes are chordate specific regulators at the intersection of Wnt and Tgf-β signaling pathways
por: Schubert, Frank Richard, et al.
Publicado: (2014)

Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling
por: Zhao, Zhiyan, et al.
Publicado: (2014)

DACT1 Involvement in the Cytoskeletal Arrangement of Cardiomyocytes in Atrial Fibrillation by Regulating Cx43
por: Hou, Jian, et al.
Publicado: (2019)

Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis
por: Boopathy, Gandhi T. K., et al.
Publicado: (2019)

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
por: Hooglugt, Aukie, et al.
Publicado: (2021)

PERCC1, a new member of the Yap/TAZ/FAM181 transcriptional co-regulator family
por: Sanchez-Pulido, Luis, et al.
Publicado: (2022)

VEGF tips its hand in angiogenesis
por: Short, Ben
Publicado: (2015)

Effect of Intranasally Delivered rh-VEGF165 on Angiogenesis Following Cerebral Hypoxia-Ischemia in the Cerebral Cortex of Newborn Piglets
por: Jain, Amit, et al.
Publicado: (2017)

VEGF siRNA delivered by polycation liposome-encapsulated calcium phosphate nanoparticles for tumor angiogenesis inhibition in breast cancer
por: Chen, Jinliang, et al.
Publicado: (2017)

RUNX Family in Hypoxic Microenvironment and Angiogenesis in Cancers
por: Lee, You Mie
Publicado: (2022)

A study to evaluate association of nuclear grooving in benign thyroid lesions with RET/PTC1 and RET/PTC3 gene translocation
por: Ashwini, Basavaraj Rangalakshmi, et al.
Publicado: (2023)

Functional characterization of castor bean (Ricinus communis) DGAT3 and DAcT enzymes in Arabidopsis thaliana
por: Trenz, Thomaz, et al.
Publicado: (2014)

Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneurons
por: Arguello, Annie, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5re81e2hm7n7dqmdsdr8blv0u5