Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages

TLRs, including TLR4, play a crucial role in inflammatory-based diseases, and TLR4 has been identified as a therapeutic target for pharmacological intervention. In previous studies, we investigated the potential of FP7, a novel synthetic glycolipid active as a TLR4 antagonist, to inhibit haematopoie...

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Detalles Bibliográficos
Autores principales: Palmer, Charys, Facchini, Fabio A, Jones, Richard PO, Neumann, Frank, Peri, Francesco, Pirianov, Grisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054148/
https://www.ncbi.nlm.nih.gov/pubmed/33858242
http://dx.doi.org/10.1177/17534259211005840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054148/
https://www.ncbi.nlm.nih.gov/pubmed/33858242
http://dx.doi.org/10.1177/17534259211005840

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