Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection

BACKGROUND: Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in children under 5 years of age in low and middle-income countries. The Flexyn2a vaccine conjugates the O-polysaccharide of Shigella flexneri 2a to Pseudomonas aeruginosa exotoxin A. We describe a Phase 2b proof-...

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Detalles Bibliográficos
Autores principales: Talaat, Kawsar R., Alaimo, Cristina, Martin, Patricia, Bourgeois, A. Louis, Dreyer, Anita M., Kaminski, Robert W., Porter, Chad K., Chakraborty, Subhra, Clarkson, Kristen A., Brubaker, Jessica, Elwood, Daniel, Frölich, Rahel, DeNearing, Barbara, Weerts, Hailey, Feijoo, Brittany L., Halpern, Jane, Sack, David, Riddle, Mark S., Fonck, Veronica Gambillara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054157/
https://www.ncbi.nlm.nih.gov/pubmed/33862589
http://dx.doi.org/10.1016/j.ebiom.2021.103310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054157/
https://www.ncbi.nlm.nih.gov/pubmed/33862589
http://dx.doi.org/10.1016/j.ebiom.2021.103310

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