Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis

Recent advances in end-to-end continuous-flow synthesis are rapidly expanding the capabilities of automated customized syntheses of small-molecule pharmacophores, resulting in considerable industrial and societal impacts; however, many hurdles persist that limit the number of sequential steps that c...

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Detalles Bibliográficos
Autores principales: Liu, Chenguang, Xie, Jiaxun, Wu, Wenbin, Wang, Mu, Chen, Weihao, Idres, Shabana Binte, Rong, Jiawei, Deng, Lih-Wen, Khan, Saif A., Wu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054510/
https://www.ncbi.nlm.nih.gov/pubmed/33875818
http://dx.doi.org/10.1038/s41557-021-00662-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054510/
https://www.ncbi.nlm.nih.gov/pubmed/33875818
http://dx.doi.org/10.1038/s41557-021-00662-w

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