Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy

In eukaryotes, the polyamine pathway generates spermidine that activates the hypusination of the translation factor eukaryotic initiation factor 5A (eIF5A). Hypusinated-eIF5A modulates translation, elongation, termination and mitochondrial function. Evidence in model organisms like drosophila sugges...

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Detalles Bibliográficos
Autores principales: Bourourou, Miled, Gouix, Elsa, Melis, Nicolas, Friard, Jonas, Heurteaux, Catherine, Tauc, Michel, Blondeau, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054730/
https://www.ncbi.nlm.nih.gov/pubmed/32615885
http://dx.doi.org/10.1177/0271678X20928882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054730/
https://www.ncbi.nlm.nih.gov/pubmed/32615885
http://dx.doi.org/10.1177/0271678X20928882

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