JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling

The overexpression of HER2 is associated with a malignant proliferation of breast cancer. In this study, we developed a non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit the proliferation of HER2-positive breast cancer cells in vitro and in vivo experimental models. JAC1 increased the u...

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Autores principales: Ren, Yanlin, Chen, Dongyin, Zhai, Zurong, Chen, Junjie, Li, Aiping, Liang, Yan, Zhou, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055679/
https://www.ncbi.nlm.nih.gov/pubmed/33875644
http://dx.doi.org/10.1038/s41420-021-00426-y
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author Ren, Yanlin
Chen, Dongyin
Zhai, Zurong
Chen, Junjie
Li, Aiping
Liang, Yan
Zhou, Jianwei
author_facet Ren, Yanlin
Chen, Dongyin
Zhai, Zurong
Chen, Junjie
Li, Aiping
Liang, Yan
Zhou, Jianwei
author_sort Ren, Yanlin
collection PubMed
description The overexpression of HER2 is associated with a malignant proliferation of breast cancer. In this study, we developed a non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit the proliferation of HER2-positive breast cancer cells in vitro and in vivo experimental models. JAC1 increased the ubiquitination of HER2 at the K716 site through the E3 ubiquitin ligase SMURF1 which was due to the decreased expression of NEDD4, the E3 ubiquitin ligase of SMURF1. In conclusion, JAC1 suppresses the proliferation of HER2-positive breast cancer cells through the JWA triggered HER2 ubiquitination signaling. JAC1 may serve as a potential therapeutic agent for HER2-positive breast cancer.
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spelling pubmed-80556792021-05-05 JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling Ren, Yanlin Chen, Dongyin Zhai, Zurong Chen, Junjie Li, Aiping Liang, Yan Zhou, Jianwei Cell Death Discov Article The overexpression of HER2 is associated with a malignant proliferation of breast cancer. In this study, we developed a non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit the proliferation of HER2-positive breast cancer cells in vitro and in vivo experimental models. JAC1 increased the ubiquitination of HER2 at the K716 site through the E3 ubiquitin ligase SMURF1 which was due to the decreased expression of NEDD4, the E3 ubiquitin ligase of SMURF1. In conclusion, JAC1 suppresses the proliferation of HER2-positive breast cancer cells through the JWA triggered HER2 ubiquitination signaling. JAC1 may serve as a potential therapeutic agent for HER2-positive breast cancer. Nature Publishing Group UK 2021-04-19 /pmc/articles/PMC8055679/ /pubmed/33875644 http://dx.doi.org/10.1038/s41420-021-00426-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ren, Yanlin
Chen, Dongyin
Zhai, Zurong
Chen, Junjie
Li, Aiping
Liang, Yan
Zhou, Jianwei
JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling
title JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling
title_full JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling
title_fullStr JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling
title_full_unstemmed JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling
title_short JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling
title_sort jac1 suppresses proliferation of breast cancer through the jwa/p38/smurf1/her2 signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055679/
https://www.ncbi.nlm.nih.gov/pubmed/33875644
http://dx.doi.org/10.1038/s41420-021-00426-y
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