An optimized protocol for patient-derived xenograft in humanized mice to evaluate the role of IL-34 in immunotherapeutic resistance

Previously, we identified a therapy-resistant role of IL-34 in an immune checkpoint blockade in murine models. To investigate whether a similar mechanism is applicable in human tumors as well, we used this protocol for the selection of IL-34-neutralizing antibody and transplanting human tumor tissue...

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Detalles Bibliográficos
Autores principales: Han, Nanumi, Jang, Hye Yoon, Hama, Naoki, Kobayashi, Takuto, Otsuka, Ryo, Wada, Haruka, Seino, Ken-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055705/
https://www.ncbi.nlm.nih.gov/pubmed/33899027
http://dx.doi.org/10.1016/j.xpro.2021.100460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055705/
https://www.ncbi.nlm.nih.gov/pubmed/33899027
http://dx.doi.org/10.1016/j.xpro.2021.100460

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