STING enhances cell death through regulation of reactive oxygen species and DNA damage

Resistance to DNA-damaging agents is a significant cause of treatment failure and poor outcomes in oncology. To identify unrecognized regulators of cell survival we performed a whole-genome CRISPR-Cas9 screen using treatment with ionizing radiation as a selective pressure, and identified STING (stim...

Descripción completa

Detalles Bibliográficos
Autores principales: Hayman, Thomas J., Baro, Marta, MacNeil, Tyler, Phoomak, Chatchai, Aung, Thazin Nwe, Cui, Wei, Leach, Kevin, Iyer, Radhakrishnan, Challa, Sreerupa, Sandoval-Schaefer, Teresa, Burtness, Barbara A., Rimm, David L., Contessa, Joseph N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055995/
https://www.ncbi.nlm.nih.gov/pubmed/33875663
http://dx.doi.org/10.1038/s41467-021-22572-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055995/
https://www.ncbi.nlm.nih.gov/pubmed/33875663
http://dx.doi.org/10.1038/s41467-021-22572-8

Ejemplares similares