Cargando…

CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism

B-cell acute lymphocytic leukemia (B-ALL) is a malignant blood cancer that develops in children and adults and leads to high mortality. THZ1, a covalent cyclin-dependent kinase 7 (CDK7) inhibitor, shows anti-tumor effects in various cancers by inhibiting cell proliferation and inducing apoptosis. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abudureheman, Tuersunayi, Xia, Jing, Li, Ming-Hao, Zhou, Hang, Zheng, Wei-Wei, Zhou, Neng, Shi, Rong-Yi, Zhu, Jian-Min, Yang, Li-Ting, Chen, Li, Zheng, Liang, Xue, Kai, Qing, Kai, Duan, Cai-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056175/ https://www.ncbi.nlm.nih.gov/pubmed/33889549 http://dx.doi.org/10.3389/fonc.2021.663360

Ejemplares similares

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism
por: Huang, Wen-Li, et al.
Publicado: (2021)

Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis
por: Zhang, Meng-Yi, et al.
Publicado: (2020)

Molecular mechanism of G(1) arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells
por: Tao, Yan-Fang, et al.
Publicado: (2017)

Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia
por: Tang, Chao, et al.
Publicado: (2018)

Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells
por: Li, Juntao, et al.
Publicado: (2020)

Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation
por: Ma, Xinqi, et al.
Publicado: (2018)

Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM
por: Juric, Viktorija, et al.
Publicado: (2021)

Ghost spintronic THz-emitter-array microscope
por: Chen, Si-Chao, et al.
Publicado: (2020)

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
por: Cayrol, Florencia, et al.
Publicado: (2017)

ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942
por: Sava, Georgina P., et al.
Publicado: (2019)

Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1
por: Wang, Yueyuan, et al.
Publicado: (2022)

Broadband THz to NIR up-converter for photon-type THz imaging
por: Bai, Peng, et al.
Publicado: (2019)

CDK6 Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia
por: Liu, Wei, et al.
Publicado: (2021)

Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors
por: Cayrol, Florencia, et al.
Publicado: (2017)

SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression
por: Wang, Fangce, et al.
Publicado: (2021)

The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5′ and 3′ ends of genes
por: Sampathi, Shilpa, et al.
Publicado: (2019)

THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours
por: Sun, Jianyi, et al.
Publicado: (2022)

HuR Affects Proliferation and Apoptosis of Chronic Lymphocytic Leukemia Cells via NF-κB Pathway
por: Xiao, Kai, et al.
Publicado: (2020)

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation
por: Juric, Viktorija, et al.
Publicado: (2021)

Monitoring leaf water content with THz and sub-THz waves
por: Gente, Ralf, et al.
Publicado: (2015)

Coherent THz Hyper-Raman: Spectroscopy and Application in THz Detection
por: Ceraso, Arianna, et al.
Publicado: (2019)

Targeting Cdk5 for killing of breast cancer cells via perturbation of redox homeostasis
por: NavaneethaKrishnan, Saranya, et al.
Publicado: (2018)

Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells
por: Li, Mengyao, et al.
Publicado: (2022)

Exploiting Cell-To-Cell Variability To Detect Cellular Perturbations
por: Dey, Gautam, et al.
Publicado: (2014)

Polarization-Insensitive Broadband THz Absorber Based on Circular Graphene Patches
por: Qian, Jiajia, et al.
Publicado: (2021)

c-Myc regulates the CDK1/cyclin B1 dependent-G(2)/M cell cycle progression by histone H4 acetylation in Raji cells
por: Yang, Yan, et al.
Publicado: (2018)

c-Myc regulates the CDK1/cyclin B1 dependent-G2/M cell cycle progression by histone H4 acetylation in Raji cells
por: Yang, Yan, et al.
Publicado: (2019)

Cellular origin and pathophysiology of chronic lymphocytic leukemia
por: Seifert, Marc, et al.
Publicado: (2012)

Generation of THz frequency using PANDA ring resonator for THz imaging
por: Jalil, MA, et al.
Publicado: (2012)

Exploring the Antitumor Mechanism of High-Dose Cytarabine through the Metabolic Perturbations of Ribonucleotide and Deoxyribonucleotide in Human Promyelocytic Leukemia HL-60 Cells
por: Li, Zheng, et al.
Publicado: (2017)

Simulation of THz Oscillations in Semiconductor Devices Based on Balance Equations
por: Linn, Tobias, et al.
Publicado: (2020)

CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer
por: Wang, Jian, et al.
Publicado: (2020)

STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia
por: Qiu, Zhi-Yuan, et al.
Publicado: (2013)

Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
por: Zou, Yixin, et al.
Publicado: (2018)

NCAPG Promotes the Proliferation of Renal Clear Cell Carcinoma via Mediating with CDK1
por: Li, Huibing, et al.
Publicado: (2022)

A Review of THz Modulators with Dynamic Tunable Metasurfaces
por: Wang, Lan, et al.
Publicado: (2019)

THz and Security Applications
por: Corsi, Carlo, et al.
Publicado: (2014)

Prognostic Significance of NLR About NETosis and Lymphocytes Perturbations in Localized Renal Cell Carcinoma With Tumor Thrombus
por: Shang, Bingqing, et al.
Publicado: (2021)

Effect of THz spectra of L-Arginine molecules by the combination of water molecules
por: Wang, Haiqing, et al.
Publicado: (2022)

Current state of NK cell-mediated immunotherapy in chronic lymphocytic leukemia
por: Wang, Zong-Han, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_516vqpcv0u906fjc4fh8j4pfbd