Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation

Apart from its physiological role in inflammation and immunity, the nuclear factor-kappa B (NF-κB) protein complex has been implicated in tumorigenesis and its progression. Here, we provide evidence that a pro-oxidant milieu is an upstream effector of oncogenic NF-κB signaling. Through pharmacologic...

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Detalles Bibliográficos
Autores principales: Yee, Yi Hui, Chong, Stephen Jun Fei, Kong, Li Ren, Goh, Boon Cher, Pervaiz, Shazib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056462/
https://www.ncbi.nlm.nih.gov/pubmed/33838472
http://dx.doi.org/10.1016/j.redox.2020.101834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056462/
https://www.ncbi.nlm.nih.gov/pubmed/33838472
http://dx.doi.org/10.1016/j.redox.2020.101834

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