RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer

BACKGROUND: Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors throughout all molecular subtypes. MIBCs with neuroendocrine features have a high response rate to immunity checkpoint inhibitors (ICIs). Whether the presence o...

Descripción completa

Detalles Bibliográficos
Autores principales: Manzano, Ramon Gonzalez, Catalan-Latorre, Ana, Brugarolas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056512/
https://www.ncbi.nlm.nih.gov/pubmed/33879103
http://dx.doi.org/10.1186/s12885-021-08078-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056512/
https://www.ncbi.nlm.nih.gov/pubmed/33879103
http://dx.doi.org/10.1186/s12885-021-08078-y

Ejemplares similares