Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

AIM: We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation. The enzyme nSMase2 is involved in the production of exosomes carryi...

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Detalles Bibliográficos
Autores principales: Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056538/
https://www.ncbi.nlm.nih.gov/pubmed/33875010
http://dx.doi.org/10.1186/s13041-021-00776-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056538/
https://www.ncbi.nlm.nih.gov/pubmed/33875010
http://dx.doi.org/10.1186/s13041-021-00776-9

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