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High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

BACKGROUND: Immune ageing is a result of repetitive microbial challenges along with cell intrinsic or systemic changes occurring during ageing. Mice under ‘specific-pathogen-free’ (SPF) conditions are frequently used to assess immune ageing in long-term experiments. However, physiological pathogenic...

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Detalles Bibliográficos
Autores principales:	Nikolaou, Christos, Muehle, Kerstin, Schlickeiser, Stephan, Japp, Alberto Sada, Matzmohr, Nadine, Kunkel, Desiree, Frentsch, Marco, Thiel, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056611/ https://www.ncbi.nlm.nih.gov/pubmed/33879187 http://dx.doi.org/10.1186/s12979-021-00230-3

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