Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

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To date the locus with the most robust human genetic association to COVID-19 susceptibility is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as p...

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Detalles Bibliográficos
Autores principales: Kasela, Silva, Daniloski, Zharko, Jordan, Tristan X., tenOever, Benjamin R., Sanjana, Neville E., Lappalainen, Tuuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057256/
https://www.ncbi.nlm.nih.gov/pubmed/33880488
http://dx.doi.org/10.1101/2021.04.09.21255184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057256/
https://www.ncbi.nlm.nih.gov/pubmed/33880488
http://dx.doi.org/10.1101/2021.04.09.21255184

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