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Neonatal valproic acid exposure produces altered gyrification related to increased parvalbumin-immunopositive neuron density with thickened sulcal floors

Valproic acid (VPA) treatment is associated with autism spectrum disorder in humans, and ferrets can be used as a model to test this; so far, it is not known whether ferrets react to developmental VPA exposure with gyrencephalic abnormalities. The current study characterized gyrification abnormaliti...

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Detalles Bibliográficos
Autores principales: Sawada, Kazuhiko, Kamiya, Shiori, Aoki, Ichio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057614/
https://www.ncbi.nlm.nih.gov/pubmed/33878144
http://dx.doi.org/10.1371/journal.pone.0250262