CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors

Limiting the metabolic competition in the tumor microenvironment (TME) may increase the effectiveness of immunotherapy. Because of its critical role in glucose metabolism of activated T cells, CD28 signaling has been proposed as a T-cell metabolic biosensor(1). Conversely, CTLA-4 engagement has been...

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Detalles Bibliográficos
Autores principales: Zappasodi, Roberta, Serganova, Inna, Cohen, Ivan J., Maeda, Masatomo, Shindo, Masahiro, Senbabaoglu, Yasin, Watson, McLane J., Leftin, Avigdor, Maniyar, Rachana, Verma, Svena, Lubin, Matthew, Ko, Myat, Mane, Mayuresh M., Zhong, Hong, Liu, Cailian, Ghosh, Arnab, Abu-Akeel, Mohsen, Ackerstaff, Ellen, Koutcher, Jason A., Ho, Ping-Chih, Delgoffe, Greg M., Blasberg, Ronald, Wolchok, Jedd D., Merghoub, Taha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057670/
https://www.ncbi.nlm.nih.gov/pubmed/33588426
http://dx.doi.org/10.1038/s41586-021-03326-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057670/
https://www.ncbi.nlm.nih.gov/pubmed/33588426
http://dx.doi.org/10.1038/s41586-021-03326-4

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