Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Aβ transfer receptor expression in mouse brain microvessels

HIV-1 transactivator protein (Tat) induces tight junction (TJ) dysfunction and amyloid-beta (Aβ) clearance dysfunction, contributing to the development and progression of HIV-1-associated neurocognitive disorder (HAND). The Rho/ROCK signaling pathway has protective effects on neurodegenerative disea...

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Detalles Bibliográficos
Autores principales: Chen, Qiangtang, Wu, Yu, Yu, Yachun, Wei, Junxiang, Huang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057965/
https://www.ncbi.nlm.nih.gov/pubmed/33548010
http://dx.doi.org/10.1007/s11010-021-04056-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057965/
https://www.ncbi.nlm.nih.gov/pubmed/33548010
http://dx.doi.org/10.1007/s11010-021-04056-x

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