Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety

PURPOSE: Pharmacometric models provide useful tools to aid the rational design of clinical trials. This study evaluates study design-, drug-, and patient-related features as well as analysis methods for their influence on the power to demonstrate a benefit of pharmacogenomics (PGx)-based dosing rega...

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Detalles Bibliográficos
Autores principales: Minichmayr, Iris K., Karlsson, Mats O., Jönsson, Siv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057977/
https://www.ncbi.nlm.nih.gov/pubmed/33733372
http://dx.doi.org/10.1007/s11095-021-03024-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057977/
https://www.ncbi.nlm.nih.gov/pubmed/33733372
http://dx.doi.org/10.1007/s11095-021-03024-w

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