PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages

NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is restricted to monocytic lineages such as monocytes, macrophage...

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Detalles Bibliográficos
Autores principales: Yashiro, Takuya, Yamamoto, Machiko, Araumi, Sanae, Hara, Mutsuko, Yogo, Kyoko, Uchida, Koichiro, Kasakura, Kazumi, Nishiyama, Chiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058198/
https://www.ncbi.nlm.nih.gov/pubmed/33897697
http://dx.doi.org/10.3389/fimmu.2021.649572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058198/
https://www.ncbi.nlm.nih.gov/pubmed/33897697
http://dx.doi.org/10.3389/fimmu.2021.649572

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