GDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2(+) Macrophage Infiltration in Mice

BACKGROUND: Checkpoint kinase 1 (CHK1) plays an important role in DNA damage response and cell cycle progression. Thus, targeting CHK1 is an efficient strategy for cancer therapy. PURPOSE: The present study aimed to investigate the potential therapeutic effects of GDC-0575, a CHK1-specific inhibitor...

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Detalles Bibliográficos
Autores principales: Li, Min, Huang, Tianqing, Li, Xiaolan, Shi, Zhiwei, Sheng, Yue, Hu, Mimi, Song, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058335/
https://www.ncbi.nlm.nih.gov/pubmed/33897258
http://dx.doi.org/10.2147/OTT.S297132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058335/
https://www.ncbi.nlm.nih.gov/pubmed/33897258
http://dx.doi.org/10.2147/OTT.S297132

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