Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity

Trastuzumab (TZM) is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.035 mg/kg/day lisinopril, 5 mg/kg/day...

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Detalles Bibliográficos
Autores principales: Olorundare, Olufunke Esan, Adeneye, Adejuwon Adewale, Akinsola, Akinyele Olubiyi, Ajayi, Abayomi Mayowa, Agede, Olalekan Ayodele, Soyemi, Sunday Sokunle, Mgbehoma, Alban Ikenna, Okoye, Ikechukwu Innocent, Albrecht, Ralph M., Ntambi, James Mukasa, Crooks, Peter Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058606/
https://www.ncbi.nlm.nih.gov/pubmed/33897413
http://dx.doi.org/10.3389/fphar.2020.610331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058606/
https://www.ncbi.nlm.nih.gov/pubmed/33897413
http://dx.doi.org/10.3389/fphar.2020.610331

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