Cargando…

Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity

Trastuzumab (TZM) is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.035 mg/kg/day lisinopril, 5 mg/kg/day...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olorundare, Olufunke Esan, Adeneye, Adejuwon Adewale, Akinsola, Akinyele Olubiyi, Ajayi, Abayomi Mayowa, Agede, Olalekan Ayodele, Soyemi, Sunday Sokunle, Mgbehoma, Alban Ikenna, Okoye, Ikechukwu Innocent, Albrecht, Ralph M., Ntambi, James Mukasa, Crooks, Peter Anthony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058606/ https://www.ncbi.nlm.nih.gov/pubmed/33897413 http://dx.doi.org/10.3389/fphar.2020.610331

Ejemplares similares

Irvingia gabonensis Seed Extract: An Effective Attenuator of Doxorubicin-Mediated Cardiotoxicity in Wistar Rats
por: Olorundare, Olufunke, et al.
Publicado: (2020)

African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats
por: Olorundare, Olufunke, et al.
Publicado: (2020)

Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo
por: Folahan, Joy Temiloluwa, et al.
Publicado: (2023)

Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats
por: Olorundare, Olufunke Esan, et al.
Publicado: (2020)

Right ventricular dysplasia in the elderly: a case report from autopsy
por: Mgbehoma, Alban Ikenna, et al.
Publicado: (2021)

Combined Intranasal Insulin/Saxagliptin/Metformin Therapies Ameliorate the Effect of Combined Oral Contraceptive- (COC-) Induced Metabolic Syndrome (MetS) with a Major Target on Glucose Metabolism in Adult Female Wistar Rats
por: Afolabi, Saheed Olanrewaju, et al.
Publicado: (2021)

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats
por: Adeneye, Adejuwon Adewale, et al.
Publicado: (2019)

Modulatory potentials of the aqueous stem bark extract of Mangifera indica on carbon tetrachloride-induced hepatotoxicity in rats
por: Adeneye, Adejuwon Adewale, et al.
Publicado: (2015)

Modulatory effect of Mangifera indica against carbon tetrachloride induced kidney damage in rats
por: Awodele, Olufunsho, et al.
Publicado: (2015)

Hypertension and Sudden Unexpected Deaths: An Autopsy Study of Four Hundred and Seventy-Seven Brought-in-Dead in a Tertiary Health Center
por: Faduyile, Francis Adedayo, et al.
Publicado: (2019)

Announcing the novel class of GABA–A receptor selective positive allosteric modulator antidepressants
por: Fasipe, Olumuyiwa John, et al.
Publicado: (2020)

Spectrum of intracranial tumours in a tertiary health carefacility: our findings
por: Soyemi, Sunday Sokunle, et al.
Publicado: (2015)

Assessment of PMTCT Success Rates Based on Antiretroviral Interventions and Feeding Options: A Prospective Cohort Study
por: Fasakin, Kolawole A., et al.
Publicado: (2018)

Survey of Hypertension, Diabetes and Obesity in Three Nigerian Urban Slums
por: PHEABIAN AKINWALE, Olaoluwa, et al.
Publicado: (2013)

Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
por: Ojuade, Fatimoh Idowu, et al.
Publicado: (2021)

Evaluation of neurotoxicity and hepatotoxicity effects of acute and sub-acute oral administration of unripe ackee (Blighia sapida) fruit extract
por: Ajayi, Abayomi Mayowa, et al.
Publicado: (2019)

Dose and time-dependent sub-chronic toxicity study of hydroethanolic leaf extract of Flabellaria paniculata Cav. (Malpighiaceae) in rodents
por: Akindele, Abidemi J., et al.
Publicado: (2014)

Adverse events following COVID-19 vaccination in Kwara State, North-central Nigeria
por: Odeigah, Louis Okeibunor, et al.
Publicado: (2022)

Renal risk profiling in newly diagnosed hypertensives in an urban population in Nigeria
por: Gbadegesin, Aderoju, et al.
Publicado: (2019)

Chrysophyllum albidum (African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines
por: Ajayi, Abayomi Mayowa, et al.
Publicado: (2020)

Forensic odontological observations in the victims of DANA air crash
por: Obafunwa, John Oladapo, et al.
Publicado: (2015)

Clustering of chronic kidney disease and cardiovascular risk factors in South-West Nigeria
por: Oluyombo, Rotimi, et al.
Publicado: (2017)

Protective Effects of Morin Hydrate on Acute Stress-Induced Behavioral and Biochemical Alterations in Mice
por: Olonode, Elizabeth Toyin, et al.
Publicado: (2018)

Anti-nociceptive and anti-inflammatory potentials of Vernonia amygdalina leaf extract via reductions of leucocyte migration and lipid peroxidation
por: Onasanwo, Samuel Adetunji, et al.
Publicado: (2017)

Traditional birth attendants’ knowledge, preventive and management practices for postpartum haemorrhage in Osun State, Southwestern Nigeria
por: Esan, Deborah Tolulope, et al.
Publicado: (2023)

Forensic Investigation of mass disasters in Nigeria: A review
por: Obafunwa, John Oladapo, et al.
Publicado: (2015)

Effects of Jobelyn(®) on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice
por: Asehinde, Stephen, et al.
Publicado: (2018)

Histomorphological Alterations in the Prostate Gland and Epithelium of Seminiferous Tubule of Sprague-Dawley Rats Treated with Methanolic Extract of Momordica charantia Seeds
por: boetse, Yama Oshiozokhai, et al.
Publicado: (2011)

The significance of sleep quality in euthymic bipolar patients from Nigeria
por: Esan, Oluyomi, et al.
Publicado: (2022)

Nutritional and Pharmaceutical Applications of Under-Explored Knottin Peptide-Rich Phytomedicines
por: Attah, Francis Alfred, et al.
Publicado: (2022)

Knowledge, attitude and practice of antenatal mothers toward urinary tract infection in selected health facilities in Ekiti state, Nigeria
por: Esan, Deborah Tolulope, et al.
Publicado: (2023)

Mistrust in government and COVID-19 vaccination acceptance in Nigeria: investigating the indirect roles of attitudes towards vaccination
por: Olawa, Babatola, et al.
Publicado: (2023)

Lopinavir/ritonavir use in Covid-19 infection: is it completely non-beneficial?
por: Owa, Adewale Bayode, et al.
Publicado: (2020)

A prospective cohort study on comparison of early outcome of classical Ponseti and modified Ponseti post tenotomy in clubfoot management
por: Mejabi, Joseph Olorunsogo, et al.
Publicado: (2017)

Models for Predicting Time to Sputum Conversion Among Multi-Drug Resistant Tuberculosis Patients in Lagos, South–West Nigeria
por: Akinsola, Oluwatosin J., et al.
Publicado: (2018)

Psychological distress experiences of Nigerians during Covid-19 pandemic; the gender difference
por: Olaseni, Abayomi O., et al.
Publicado: (2020)

Interactions Between Socioeconomic Status and Mental Health Outcomes in the Nigerian Context Amid COVID-19 Pandemic: A Comparative Study
por: Agberotimi, Samson F., et al.
Publicado: (2020)

Risk of manic switch with antidepressants use in patients with bipolar disorder in a Nigerian neuropsychiatric hospital
por: Fela-Thomas, Ayodele L., et al.
Publicado: (2018)

Ethylene glycol monomethyl ether-induced testicular oxidative stress and time-dependent up-regulation of apoptotic, pro-inflammatory, and oncogenic markers in rats
por: Somade, Oluwatobi T., et al.
Publicado: (2020)

Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies
por: Afolabi, Saheed O., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6357kmkh0h9dq94j2fvn4taffr