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Ca(2+)-saturated calmodulin binds tightly to the N-terminal domain of A-type fibroblast growth factor homologous factors

Voltage-gated sodium channels (Na(v)s) are tightly regulated by multiple conserved auxiliary proteins, including the four fibroblast growth factor homologous factors (FGFs), which bind the Na(v) EF-hand like domain (EFL), and calmodulin (CaM), a multifunctional messenger protein that binds the Na(V)...

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Detalles Bibliográficos
Autores principales: Mahling, Ryan, Rahlf, Cade R., Hansen, Samuel C., Hayden, Matthew R., Shea, Madeline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059062/
https://www.ncbi.nlm.nih.gov/pubmed/33639159
http://dx.doi.org/10.1016/j.jbc.2021.100458