Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

BACKGROUND: Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can integrate multiple neoantigens simultaneousl...

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Detalles Bibliográficos
Autores principales: Li, Lijin, Zhang, Xiuli, Wang, Xiaoli, Kim, Samuel W., Herndon, John M., Becker-Hapak, Michelle K., Carreno, Beatriz M., Myers, Nancy B., Sturmoski, Mark A., McLellan, Michael D., Miller, Christopher A., Johanns, Tanner M., Tan, Benjamin R., Dunn, Gavin P., Fleming, Timothy P., Hansen, Ted H., Goedegebuure, S. Peter, Gillanders, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059244/
https://www.ncbi.nlm.nih.gov/pubmed/33879241
http://dx.doi.org/10.1186/s13073-021-00872-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059244/
https://www.ncbi.nlm.nih.gov/pubmed/33879241
http://dx.doi.org/10.1186/s13073-021-00872-4

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